Nationally and in Colorado, drug use disorders and fatal overdoses remain significant public health concerns. Drug overdose deaths were further classified according to the involvement of specific substances, including prescription opioid analgesics (prescription opioids), illicit opioids (including heroin), methamphetamine and cocaine, and manner (intent) of the overdose, including unintentional (accidental), intentional self-harm (suicide), and those of undetermined intent.