The producing formations of the Denver-Julesburg Basin are currently being economically recovered in the Greater Wattenberg Area (GWA) of north-central Colorado for gas and oil condensate. Production has occurred mainly in southwestern Weld County. Data and trend analysis were performed to assess the distribution and long-term changes in the groundwater quality in the GWA. The intent of the analysis was to identify any short or long-term trends that might indicate that oil and gas drilling and production activities are impacting domestic water wells in the GWA. Therefore, emphasis was placed on a subset of constituents that could indicate potential impacts from drilling and production activities.