This study proposes that a number of geographic, demographic, and economic factors are driving investment and engagement in innovation in the agricultural and food system, and the essential elements are in place along the Colorado Front Range for the emergence and growth of an innovation-led industry cluster in agriculture and food. Innovators in an increasingly integrated agriculture-water-food-beverage-bioenergy innovation ecosystem are gathering and growing along Colorado's Front Range, creating next-generation technologies and business models to nourish, refresh, and energize the world.